Foks, Henryk published the artcilePyrazine derivatives. IX. Synthesis and tuberculostatic activity of 2-pyrazinylbenzimidazoles, Computed Properties of 4604-72-2, the publication is Acta Poloniae Pharmaceutica (1978), 35(3), 281-8, database is CAplus and MEDLINE.
Twenty-eight benzimidazole derivatives [I, R = H, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 4-methyl-1-piperazinyl, Me2NNH, 1-imidazolyl, 2-, 3- and 4-EtC6H4; R1 = H, 5-Cl, 5-Br, 5-NO2, 4- and 5-Me] were prepared in 30-80% yields by fusion of 6-substituted 2-thiocarbamoylpyrazines with appropriate o-(NH2)2C6H4 derivatives 2-(2-Pyridinyl)benzimidazole (II), the 3- and 4-pyridinyl analogs of II, 2-(2-ethyl-4-pyridinyl)benzimidazole (III) and the 5-Me and 5-Cl analogs of III as well as IV and its [4,5-c] analog were prepared analogously. Similarly, 12 I (R = MeO and EtO; R1 as above) were prepared by fusing the 6-methoxy and 6-ethoxy derivatives, resp., of pyrazine-2-carboximidic acid esters with the appropriate o-(NH2)2C6H4 derivatives All compounds prepared revealed moderate tuberculostatic activity against H37Rv and Sp 607 strains; their activity was particularly interesting in the case of strains resistant to ethionamide.
Acta Poloniae Pharmaceutica published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Computed Properties of 4604-72-2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem