Dhumal, Sambhaji T. published the artcileSynthesis and Antitubercular activity of New Thiazolidinones with Pyrazinyl and Thiazolyl scaffolds, Category: pyrazines, the publication is Journal of Heterocyclic Chemistry (2017), 54(1), 125-130, database is CAplus.
Emergence of multidrug resistant and extensively drug resistant tuberculosis has prompted to develop new mol. entities to treat the disease. A series of new 4-thiazolidinones with pyrazinyl and thiazolyl scaffolds has been synthesized, and their antitubercular activity is reported. The title 4-thiazolidinones, N-(pyrazinyl substituted thiazoloylamino)-2-aryl-4-thiazolidinones I [ R = H, 4-Me, 2-F, etc] have been first time prepared using pyrazinamide as a starting material via five successive steps. The purity and the structures of the intermediates (carboethoxythiazole, acid hydrazide, and azomethines) and title thiazolidinones I [ R = H, 4-Me, 2-F, etc] have been confirmed by TLC and spectral analyses, resp. An antitubercular screening of the new 4-thiazolidinones has been performed on bacterial strains, Mycobacterium tuberculosis H37Ra and Mycobacterium BCG using the solutions of different concentrations of the compounds I [ R = H, 4-Me, 2-F, etc] and the screening results are presented. Compound I [ R = H] has displayed notable antitubercular activity.
Journal of Heterocyclic Chemistry published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Category: pyrazines.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem