Biedulska, Malgorzata published the artcilePhysicochemical profile of Os (III) complexes with pyrazine derivatives: From solution behavior to DNA binding studies and biological assay, Application In Synthesis of 4604-72-2, the publication is Journal of Molecular Liquids (2020), 113804, database is CAplus.
New series of osmium(III) complexes with pyrazinamide (PZA) and its analogs (PTCA, PAOX) were synthesized. The physicochem. features in the solid phase have been identified and confirmed using elemental anal., mass spectrometry, spectroscopic techniques (FT-IR, 1H NMR) and thermogravimetric anal. Based on the studies we confirmed bidentate nature of selected pyrazine derivatives and proven involvement azomethine and amine nitrogen atoms in coordination of metal ion. In particular, complex (2) is more stable than (1) and (3), retaining thermal stability up to 120 °C. After one stage dehydration process, the simultaneous destruction of Os(III) complexes architecture was observed with immediate decomposition and elimination of pyrazine derivatives The acid-base equilibrium studies of newly synthesized Os(III) complexes were carried out by combined pH-metric-spectrophotometric and potentiometric titrations in the aqueous solution Os(III) complexes exhibited rich redox chem. as demonstrated by cyclic voltammetry. The cyclic voltammograms revealed a well-defined redox couples which correspond to reversible, single-electron OsIII → OsII reduction within -1.152 to -1.374 V vs Ag/AgCl and OsIII → OsIV oxidation within 0.460-0.831 V vs Ag/AgCl. The binding ability of bioactive ligand and their Os(III) complexes with Calf Thymus DNA (CT-DNA) were investigated by spectrophotometric titration The observed hypsochromic and bathochromic shifts with simultaneous hyperchromic effect confirmed mixed mode of interaction with biol. target. Biol. activity of Os(III) complexes, i.e. antimicrobial, cytotoxic, haemolytic and photodynamic potential were studied.
Journal of Molecular Liquids published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Application In Synthesis of 4604-72-2.
Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem