Schafer, Gabriel published the artcileScalable Synthesis of Trifluoromethylated Imidazo-Fused N-Heterocycles Using TFAA and Trifluoroacetamide as CF3-Reagents, Computed Properties of 39204-49-4, the main research area is heterocyclic benzylamine trifluoroacetic anhydride dehydrative cyclization; trifluoromethylated imidazo fused nitrogen heterocycle preparation.
A scalable synthesis of trifluoromethylated imidazo-fused N-heterocycles, e.g. I, from heterocyclic benzylamines using TFAA as trifluoromethylating reagent is presented. The reaction proceeds via intermediate benzylic N-trifluoroacetamides followed by dehydrative cyclization to the products. To further broaden the scope and practicality, a new method for the preparation of benzylic N-trifluoroacetamides via alkylation of trifluoroacetamide with benzyl (pseudo)halides was developed. Both methods proceed under mild conditions, and their symbiosis provides access to a wide range of novel CF3-heterocycles.
Organic Letters published new progress about Cyclization. 39204-49-4 belongs to class pyrazines, name is Pyrazin-2-ylmethanamine hydrochloride, and the molecular formula is C5H8ClN3, Computed Properties of 39204-49-4.