Hosoya, Takamitsu published the artcileConcise Synthesis of v-Coelenterazines, HPLC of Formula: 566205-01-4, the main research area is coelenterazine vinylene analog preparation luminescence Renilla luciferase substrate; vinylene coelenterazine preparation cross coupling ring closing metathesis.
A novel synthetic method for v-coelenterazine (v-CTZ), I (R = OH), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-coupling reactions and ring-closing metathesis (RCM). A newly synthesized C2-modified trifluoromethyl analog cf3-v-CTZ, I (R = CF3), showed slightly more red-shifted luminescence than v-CTZ when it was used as a substrate for Renilla luciferases.
Organic Letters published new progress about Bioluminescence. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, HPLC of Formula: 566205-01-4.