Martin, Matthew W. published the artcileDiscovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11, Synthetic Route of 799557-87-2, the main research area is hydroxy arylisoindoline carboxamide derivative HDAC11 inhibitor antitumor antiinflammatory; HDAC11; HDACs; Hydroxamic acid; Inflammation; Isoindoline; Oncology.
N-Hydroxy-2-arylisoindoline-4-carboxamides are potent and selective inhibitors of HDAC11. The discovery, synthesis, and structure activity relationships of this novel series of inhibitors are reported. An advanced analog (FT895) displays promising cellular activity and pharmacokinetic properties that make it a useful tool to study the biol. of HDAC11 and its potential use as a therapeutic target for oncol. and inflammation indications.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 799557-87-2 belongs to class pyrazines, name is 2-Chloro-5-(trifluoromethyl)pyrazine, and the molecular formula is C5H2ClF3N2, Synthetic Route of 799557-87-2.