Lumma, William C. Jr. published the artcilePiperazinylimidazo[1,2-a]pyrazines with selective affinity for in vitro α-adrenergic receptor subtypes, Name: 8-Bromoimidazo[1,2-a]pyrazine, the main research area is piperazinylimidazopyrazine preparation alpha adrenergic agonist; potential energy piperazinylimidazopyrazine; conformation piperazinylimidazopyrazine; NMR piperazinylimidazopyrazine; structure activity piperazinylimidazopyrazine.
The title compounds I (R = H, etc.; R1 = H, Cl, Me, etc.; R2 = H, piperazinyl, etc.; R3 = H, Cl, Ph, piperazinyl; R4 = H, piperazino or methylpiperazino) were prepared and evaluated in vitro for their affinity for α1- and α2-adrenergic receptors. 8-(1-piperazinyl)imidazo[1,2-a]pyrazine (II) [76537-53-6] was ∼70 times more selective than mianserin for the α2-receptor. Computer-assisted mol. modeling techniques were used to describe possible preferred conformations for receptor binding. Regioselective syntheses of the heterocyclic ring system are given. Literature NMR assignments for the imidazo[1,2-a]pyrazine ring system were made. Conformational energies for II and its 5-position isomer in relation to the semirigid mianserin were estimated Structure-activity relations are discussed.
Journal of Medicinal Chemistry published new progress about Molecular mechanics. 69214-34-2 belongs to class pyrazines, name is 8-Bromoimidazo[1,2-a]pyrazine, and the molecular formula is C6H4BrN3, Name: 8-Bromoimidazo[1,2-a]pyrazine.