Lin, Songnian published the artcileNovel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2), Product Details of C5H5ClN4O, the main research area is aminopyrazine amine isothiocyanate condensation; aminopyrazinylmethyl thiourea preparation antiinflammatory antiarthritis; protein kinase 2 inhibition structure activity.
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas, i.e. I, are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biol. evaluation of these compounds are discussed.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 1125-56-0 belongs to class pyrazines, name is 3-Amino-6-chloropyrazine-2-carboxamide, and the molecular formula is C5H5ClN4O, Product Details of C5H5ClN4O.