Holt, Alaina K. published the artcileIdentification of gamma-butyrolactone in JUUL liquids, Safety of 2,3,5-Trimethylpyrazine, the main research area is gamma butyrolactone JUUL liquid identification.
Gamma-butyrolactone (GBL), a commonly used industrial solvent, is used recreationally as a central nervous system (CNS) depressant and, therefore, is a United States Drug Enforcement Agency List 1 chem. of the Controlled Substances Act. GBL was identified presumptively in the liquid from JUUL Virginia Tobacco flavored pods during routine untargeted screening anal. of e-cigarette products by gas chromatog.-mass spectrometry (GC-MS). Methods for the anal. of GBL were developed for GC-MS and liquid chromatog.-tandem mass spectrometry (LC-MS-MS) in the liquids and the aerosol generated from the liquid Three flavors of JUUL pods available at the time of anal. were obtained by direct purchase from the manufacturer, purchase from a local vape shop and submission from a third party. The only liquid flavor to contain GBL was Virginia Tobacco, with an average of 0.37 mg/mL of GBL, and it was detected in the aerosol. Studies evaluating the pharmacol. effects of inhaling GBL do not exist; however, a case report of chronic oral GBL ingestion indicates acute lung injury. The identification of GBL in an e-cigarette product purportedly compliant with federal regulation continues to demonstrate public health and public safety concerns.
Journal of Analytical Toxicology published new progress about Acute pulmonary injury. 14667-55-1 belongs to class pyrazines, name is 2,3,5-Trimethylpyrazine, and the molecular formula is C7H10N2, Safety of 2,3,5-Trimethylpyrazine.