Ding, Yun published the artcileDevelopment and Synthesis of DNA-Encoded Benzimidazole Library, Formula: C5H8ClN3, the main research area is preparation DNA conjugated benzimidazole library NK3 receptor antagonist; DNA tagged fluoronitrobenzamide amine aldehyde; DNA-encoded library technology; benzimidazole.
Encoded library technol. (ELT) is an effective approach to the discovery of novel small-mol. ligands for biol. targets. A key factor for the success of the technol. is the chem. diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.
ACS Combinatorial Science published new progress about Chemical library. 39204-49-4 belongs to class pyrazines, name is Pyrazin-2-ylmethanamine hydrochloride, and the molecular formula is C5H8ClN3, Formula: C5H8ClN3.