Kwak, Se Hun published the artcileSynthesis of N-substituted 2-aminothiazolo[4,5-b]pyrazines by tandem reaction of o-aminohalopyrazines with isothiocyanates, Formula: C4H2Br2ClN3, the main research area is pyrazine thiazole preparation tandem reaction; chloro pyrazinamine cyclization isothiocyanate; bromo aminopyrazine cyclization isothiocyanate.
Under optimized reaction conditions, the synthesis of the target compounds was achieved by a sodium hydroxide-mediated tandem reaction of isothiocyanate derivatives with 3-halo-2-pyrazinamine. A reaction of isothiocyanate derivatives with 3-chloro-2-pyrazinamine derivatives gave N-(phenyl)thiazolo[4,5-b]pyrazin-2-amine (I) and related substances.
Bulletin of the Korean Chemical Society published new progress about Azoles Role: SPN (Synthetic Preparation), PREP (Preparation). 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Formula: C4H2Br2ClN3.