Almansa, Carmen published the artcileSynthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines, Formula: C6H9N3, the main research area is pyrazolopyrimidine preparation COX2 inhibitor; pyrimidine pyrazolo preparation COX2 inhibitor; structure activity pyrazolopyrimidine COX2 inhibitor.
The synthesis and pharmacol. activity of a series of bicyclic pyrazolo[1,5-a]pyrimidines, e.g., I (R1, R2, R3 = H, Me), as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema and air-pouch model). Modification of the pyrimidine substituents showed that 6,7-disubstitution provided the best activity and led to the identification of 3-(4-fluorophenyl)-6,7-dimethyl-2-[4-(methylsulfonyl)phenyl]pyrazolo[1,5-a]pyrimidine I (R1 = H, R2 = R3 = Me) as one of the most potent and selective COX-2 inhibitors in this series.
Journal of Medicinal Chemistry published new progress about Nonsteroidal anti-inflammatory agents. 91678-81-8 belongs to class pyrazines, name is 3,5-Dimethylpyrazin-2-amine, and the molecular formula is C6H9N3, Formula: C6H9N3.