On May 5, 2022, Chen, Yi published a patent.HPLC of Formula: 87486-34-8 The title of the patent was Synthesis of Pyridine BTK inhibitors treating cancers, autoimmune and inflammatory diseases. And the patent contained the following:
The synthesis of pyridine BTK inhibitors, I, wherein Q is a 5-9 membered aryl or heteroaryl ring; Q1 is a 5-7 membered heterocycloalkyl group; Q2 can be a 5-membered heteroaryl or Ph ring; Q3 can be a 6-membered heteroaryl group; Z can be absent, alkyl ether, amine, thioether, carbonyl, sulfonyl, sulfone, ester, or related moieties; L can be absent or an appropriate linker group; the warhead is an alkene or alkyne group; R can be independently H, D, alkyl, spiroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, or related groups; R1 can be H, halo, alkyl, haloalkyl, or hydroxyalkyl; R2 can be H, halo, or low alkyl; treating cancers, autoimmune and inflammatory diseases. Of note, II was synthesized and tested in an in vitro dialysis assay WT BTK with an IC50 of 7.0 nM, in pharmacokinetics, xenograft and arthritis studies. The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).HPLC of Formula: 87486-34-8
The Article related to pyridine btk inhibitor preparation anticancer autoimmune inflammatory, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 87486-34-8