Month: November 2022

Hrynyshyn, Yevhenii V. et al. published their research in Chemistry of Heterocyclic Compounds in 2017 | CAS: 1314920-48-3

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.COA of Formula: C7H7N3O

Synthesis of 8H-pyrazolo[5′,1′:3,4]pyrazino[2,1-b]quinazolin-8-ones was written by Hrynyshyn, Yevhenii V.;Tsizorik, Nazar M.;Musiychuk, Anna R.;Bol’but, Andriy V.;Vovk, Mykhailo V.. And the article was included in Chemistry of Heterocyclic Compounds in 2017.COA of Formula: C7H7N3O The following contents are mentioned in the article:

4-Chloropyrazolo[1,5-a]pyrazines reacted with anthranilic acids forming 8H-pyrazolo[5′,1′:3,4]pyrazino[2,1-b]quinazolin-8-ones I (R1 = H, CF3, Me, NO2; R2 = H, OMe; R3 = H, Me, OMe) representing a new heterocyclic system. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3COA of Formula: C7H7N3O).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.COA of Formula: C7H7N3O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Hrynyshyn, Yevhenii V. et al. published their research in Chemistry of Heterocyclic Compounds in 2019 | CAS: 1314920-48-3

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Product Details of 1314920-48-3

Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki-Miyaura cross coupling was written by Hrynyshyn, Yevhenii V.;Musiychuk, Anna R.;Tsizorik, Nazar M.;Bol’but, Andriy V.;Vovk, Mikhailo V.. And the article was included in Chemistry of Heterocyclic Compounds in 2019.Product Details of 1314920-48-3 The following contents are mentioned in the article:

Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by the Suzuki-Miyaura cross coupling reaction of 4-bromopyrazolo[1,5-a]pyrazines with aryl(hetaryl)boronic acids in the presence of catalytic amounts of Pd(dppf)Cl2·CH2Cl2 and an excess of Cs2CO3 in the MeCN-H2O, 9:1 solvent system is discussed. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Product Details of 1314920-48-3).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Product Details of 1314920-48-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Zaremba, O. V. et al. published their research in Chemistry of Heterocyclic Compounds in 2013 | CAS: 1314920-48-3

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Category: pyrazines

Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold was written by Zaremba, O. V.;Gorobets, N. Yu.;Kovalenko, S. S.;Drushlyak, O. G.;Grevtsov, O. Yu.;Kovalenko, S. M.. And the article was included in Chemistry of Heterocyclic Compounds in 2013.Category: pyrazines The following contents are mentioned in the article:

A series of novel pyrazolo[1,5-a]pyrazine derivatives I was synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]-pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one were isolated as intermediate compounds This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Category: pyrazines).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Category: pyrazines

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Bozhanov, Vladimir I. et al. published their research in ChemistrySelect in 2022 | CAS: 1314920-48-3

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 1314920-48-3

Straightforward Synthesis of Functionalized 4,5,6,7-Tetrahydro-pyrazolo[1,5-a]pyrazines-Important Building Blocks for Medicinal Chemistry was written by Bozhanov, Vladimir I.;Bohdan, Dmytro P.;Borysov, Oleksandr V.;Silin, Aleksey V.;Zaremba, Oleg V.;Avramenko, Mykola M.;Volochnyuk, Dmitriy M.;Ryabukhin, Sergey V.;Gavrilenko, Konstantin S.. And the article was included in ChemistrySelect in 2022.Reference of 1314920-48-3 The following contents are mentioned in the article:

A set of building blocks based on the 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine e.g., I scaffold is synthesized in a multigram scale in a cost-efficient manner. The possibility of the introduction of different substituents, neutral or functionalized in different positions of pyrazole and/or piperazine rings, is shown. The efficacy of using NH-pyrazole carbonic acids as a key intermediate of the process is demonstrated. The regioselectivity for direct insertion of the substituent to the 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine core is discussed. The synthetic perspectives for using the functionalized 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine as a bifunctional scaffold is discussed. The utilizing of building blocks obtained for the different region- and/or stereoselective synthesis, including sole transformations or modifications of functional groups, is demonstrated. The advantages of the proposed approach are proven compared with the other known methodologies. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3Reference of 1314920-48-3).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 1314920-48-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Srivastava, Ruby’s team published research in Journal of Biomolecular Structure and Dynamics in 39 | CAS: 59944-75-1

Journal of Biomolecular Structure and Dynamics published new progress about 59944-75-1. 59944-75-1 belongs to pyrazines, auxiliary class Other Aromatic Heterocyclic,Amine, name is Thieno[2,3-b]pyrazin-7-amine, and the molecular formula is C11H14O2, Application of Thieno[2,3-b]pyrazin-7-amine.

Srivastava, Ruby published the artcileChemical reactivity theory (CRT) study of small drug-like biologically active molecules, Application of Thieno[2,3-b]pyrazin-7-amine, the publication is Journal of Biomolecular Structure and Dynamics (2021), 39(3), 943-952, database is CAplus and MEDLINE.

New biochem. screening and design based technol. are used to identify the small mols. in targeting RNA. These approaches has develop potential drug like small mol. for RNA-targeted therapeutics. Chem. Reactivity Theory (CRT) is used to study these drug-like, biol. active small mols. that target RNA. Twenty two small mols. based on structure (), information (), fragment (), small mol. microarrays (), and use of phenotypic assays () are selected for the studies of several DFT-based global reactivity and local reactivity descriptors to provide complete explanation for the reactivity of these complexes by chem. reactivity method. Higher HOMO-LUMO gap indicated the structural stability for the studied complexes. The complexes reflect greater thermodn. stability. Further the results predicted that high aromaticity and hardness are measures of high stability and low reactivity for the studied complexes. It was observed that a good, more reactive, nucleophile can be described by a lower value of μ, ω while a good electrophile can be described by a high value of μ, ω. TDDFT results predicted that few complexes can be used as fluorescent biomarkers as their emission wavelength lies in the visible region.

Journal of Biomolecular Structure and Dynamics published new progress about 59944-75-1. 59944-75-1 belongs to pyrazines, auxiliary class Other Aromatic Heterocyclic,Amine, name is Thieno[2,3-b]pyrazin-7-amine, and the molecular formula is C11H14O2, Application of Thieno[2,3-b]pyrazin-7-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem

Bonati, F.’s team published research in International Congress of Chemotherapy, Proceedings in 1963 | CAS: 4604-72-2

International Congress of Chemotherapy, Proceedings published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, COA of Formula: C5H5N3S.

Bonati, F. published the artcileAntibacterial activity of substituted thioamides in relation to chemical constitution, COA of Formula: C5H5N3S, the publication is International Congress of Chemotherapy, Proceedings (1964), 1963(1), 183-5, database is CAplus.

A large number of the title compounds were tested in vitro against Mycobacterium tuberculosis H37Rv, Staphylococcus aureus (Oxford strain), Escherichia coli (1st. Sieroterap. Milanese 95), Proteus vulgaris (I.S.M. 2), and Pseudomonas aeruginosa (I.S.M. 32). Structural formulas and inhibitory concentrations of the compounds are indicated for M. tuberculosis, S. aureus, and Ε. coli. For simple thioamides, inhibitory activity was almost absent for the 4 test organisms other than M. tuberculosis. The test compounds (Mannich bases) contained either 1 or 2 N atoms in their heterocyclic rings. The inhibitory concentrations for P. vulgaris and P. aeruginosa were very similar to those for Ε. coli. In antitubercular activity, the ethyl isonicotinic thioamide was superior to other thioamides, while the activity of Mannich bases derived from 3-pyridine thiocarboxamide and from pyrazinethiocarboxamide was superior to that of various other compounds

International Congress of Chemotherapy, Proceedings published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, COA of Formula: C5H5N3S.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem

Zhai, Xin’s team published research in Chemical Research in Chinese Universities in 22 | CAS: 4604-72-2

Chemical Research in Chinese Universities published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C12H9N3O4, Related Products of pyrazines.

Zhai, Xin published the artcileSynthesis and antibacterial activity of novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic groups, Related Products of pyrazines, the publication is Chemical Research in Chinese Universities (2006), 22(4), 459-464, database is CAplus.

Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic (imidazo[1,2-b]pyridazine/imidazo[2,1-b]thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate is proposed. The structures of the target compounds were confirmed by 1H NMR, IR and MS, and their in vitro antibacterial activities against Staphylococcus aureus were evaluated. Among them, I displays a promising antibacterial activity comparable to that of linezolid.

Chemical Research in Chinese Universities published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C12H9N3O4, Related Products of pyrazines.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem

Hearn, Brian R.’s team published research in Organic Letters in 8 | CAS: 4604-72-2

Organic Letters published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Application In Synthesis of 4604-72-2.

Hearn, Brian R. published the artcileC-15 Thiazol-4-yl Analogues of (E)-9,10-Didehydroepothilone D: Synthesis and Cytotoxicity, Application In Synthesis of 4604-72-2, the publication is Organic Letters (2006), 8(14), 3057-3059, database is CAplus and MEDLINE.

The syntheses and biol. evaluation of six epothilone D analogs are reported. These side-chain variants of the (E)-9,10-didehydroepothilone scaffold contain C15 thiazole appendages that are derived from bromomethyl ketone intermediates. Although each of these analogs is less cytotoxic than the parent (E)-9,10-didehydroepothilone D, three maintain IC50 values in the double-digit nanomolar range against both susceptible and resistant cell lines.

Organic Letters published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C5H5N3S, Application In Synthesis of 4604-72-2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem

Dar’in, Dmitry’s team published research in European Journal of Medicinal Chemistry in 161 | CAS: 762263-64-9

European Journal of Medicinal Chemistry published new progress about 762263-64-9. 762263-64-9 belongs to pyrazines, auxiliary class Pyrazine,Boronic acid and ester,Boronic Acids, name is Pyrazin-2-ylboronic acid, and the molecular formula is C4H5BN2O2, Computed Properties of 762263-64-9.

Dar’in, Dmitry published the artcileNon-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity, Computed Properties of 762263-64-9, the publication is European Journal of Medicinal Chemistry (2019), 526-532, database is CAplus and MEDLINE.

A novel chemotype topol. similar to known influenza virus PA endonuclease inhibitors was designed. It was aimed to reproduce the extended topol. of the known metal-chelating ligands with a p-phenylidene-linked bis-imidazoline scaffold. It was envisioned that aromatic groups introduced to this scaffolds via metal-catalyzed N-arylation (Buchwald-Hartwig or Chan-Evans-Lam) would contribute to lipophilic binding to the target and one of the imidazoline nitrogen atoms would ensure non-chelating coordination to the prosthetic divalent metal ion. The compounds displayed appreciable anti-influenza activity in vitro and substantial concentration window from the general cytotoxicity range. Docking anal. of low-energy poses of the most active compound (as well as their comparison to the binding of an inactive compound) revealed that these compounds reproduced similar binding components to a known PA endonuclease inhibitor and displayed similar binding pose and desired monodentate metal coordination, as was initially envisioned. These findings warrant further study of the mechanism of action of the newly discovered series.

European Journal of Medicinal Chemistry published new progress about 762263-64-9. 762263-64-9 belongs to pyrazines, auxiliary class Pyrazine,Boronic acid and ester,Boronic Acids, name is Pyrazin-2-ylboronic acid, and the molecular formula is C4H5BN2O2, Computed Properties of 762263-64-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem

Seko, Norihiko’s team published research in Chemical & Pharmaceutical Bulletin in 39 | CAS: 4604-72-2

Chemical & Pharmaceutical Bulletin published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C20H28B2O4S2, COA of Formula: C5H5N3S.

Seko, Norihiko published the artcileSynthesis and platelet aggregation inhibitory activity of diphenylazole derivatives. I. Thiazole and imidazole derivatives, COA of Formula: C5H5N3S, the publication is Chemical & Pharmaceutical Bulletin (1991), 39(3), 651-7, database is CAplus and MEDLINE.

Diphenylimidazoles I (X = NH, R = OMe, R1 = 2-, 3-, 4-pyridyl, 6-methyl-2-pyridyl, 2-, 3-thienyl, 5-methyl-2-thienyl, 3-methyl-2-thienyl, 2-pyrrolyl, 1,5-dimethyl-2-pyrrolyl) were prepared by the cyclocondensation of p-anisil with R1CHO in the presence of NH4OAc. Diphenylthiazoles I (X = S; R = OMe, H, F, SMe; R1 = as above) were prepared by the cyclocondensation of p-RC6H4COCHBrC6H4R-p with R1C(:S)NH2. I (X = NH, S) were tested as inhibitors of platelet aggregation in in vitro experiments Diphenylthiazoles I (X = S) were more potent than diphenylimidazoles I (X = NH) in inhibiting arachidonic acid-induced platelet aggregation of rabbit platelet-rich plasma. Two diphenylimidazole and eight diphenylthiazole derivatives were evaluated for ex vivo arachidonic acid and collagen-induced platelet aggregation inhibitory activity using guinea pigs. I (R = OMe, R1 = 1,5-dimethylpyrrol-2-yl, X = S) (II) showed strong activity in vitro and ex vivo. The ex vivo activity of II was 200 times stronger than that of aspirin.

Chemical & Pharmaceutical Bulletin published new progress about 4604-72-2. 4604-72-2 belongs to pyrazines, auxiliary class Pyrazine,Amine,Amide, name is Pyrazine-2-carbothioamide, and the molecular formula is C20H28B2O4S2, COA of Formula: C5H5N3S.

Referemce:
https://en.wikipedia.org/wiki/Pyrazine,
Pyrazine | C4H4N2 – PubChem