On October 10, 2002, Janssen, Paul Adriaan Jan; Van Aken, Koen Jeanne Alfons; Lewi, Paulus Joannes; Koymans, Lucien Maria Henricus; De Jonge, Marc Rene; Heeres, Jan; Daeyaert, Frederik Frans Desire; Hoornaert, Georges Joseph Cornelius; Compernolle, Frans Josef Cornelius; Kilonda, Amuri published a patent.COA of Formula: C5H4Br2N2O The title of the patent was Preparation of HIV inhibiting pyrazinones. And the patent contained the following:
The title compounds [I; R1 = H, OH, CN, etc.; R2 = H, halo, SH, etc.; R3, R4 = (un)substituted Ph, pyridyl, pyrimidinyl, etc.; X = O, N:N, NHNH, NR14, alkanediyl, etc.; R14 = H, aryl, formyl, etc.], useful in inhibiting HIV replication, were prepared Thus, refluxing 5-bromo-3-(4-cyanophenylamino)-1,6-dimethyl-2(1H)-pyrazinone (preparation given) with 4-hydroxy-3,5-dimethylbenzonitrile in the presence of cesium carbonate, copper(I) chloride, 1-naphthoic acid and mol. sieves 4Å in toluene for 6 days afforded II which showed IC50 of 0.0063 μM against HIV-1. The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).COA of Formula: C5H4Br2N2O
The Article related to pyrazinone preparation hiv1 inhibition aids, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C5H4Br2N2O