On August 4, 2017, Boruah, Anima; Subramanya, Hosahalli published a patent.COA of Formula: C5H4Br2N2O The title of the patent was Substituted 2-pyrazinone derivatives as kinase inhibitors and their preparation. And the patent contained the following:
The invention provides substituted 2-pyrazinone derivatives of formula I as protein kinase inhibitors, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The invention also provides methods for synthesizing and administering the protein kinase inhibitor compounds The invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. Compounds of formula I wherein dashed bonds are single and double bonds; A is absent, CH, CH2, and CHCH2; X is N, C and CH; R1 is H and (un)substituted C1-6 alkyl; R2 is H, OH, acyl, (un)substituted C1-6 alkyl; R1R2 can be taken together to form (un)substituted heterocyclyl; R3 and R7 are independently H, acyl, (un)substituted C1-6 alkyl, (un)substituted aryl, etc.; R4 and R5 are independently H, halo, CN, OH, NO2, etc.; R3R4 can be taken together to form (un)substituted carbocyclic or (un)substituted heterocyclic ring; R6 is H, halo, CN, OH, NO2, etc.; m and p are independently 0 to 2; and pharmaceutically acceptable salts, derivatives, pro-drugs, isomers, stereoisomers, solvates and biol. active metabolites thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their protein kinase inhibitory activity (some data given). The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).COA of Formula: C5H4Br2N2O
The Article related to pyrazinone preparation protein kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C5H4Br2N2O