On August 11, 2020, Yang, Shengyong; Li, Linli published a patent.Electric Literature of 87486-34-8 The title of the patent was Anti-influenza small molecule compound and preparation method and application thereof. And the patent contained the following:
Preparation and anti-influenza activity of amino(fluoropyrrolo[2,3-b]pyridinyl)pyrazinones represented by I. In particular, I is a pharmaceutically acceptable salt, or stereoisomer or solvate thereof, or its prodrugs, or its metabolites: [wherein X is selected from CR4, N; Y is selected from CR5R6, NR7, O, S; R4, R5, R6 and R7 can be independently selected from H, C1~6 alkyl substituted with 0-4 R8, 3-8 membered cycloalkyl substituted with 0-4 R9, aryl or heteroaryl substituted with 0-4 R10; R8 is selected from 3~8 membered cycloalkyl, halogen, carboxyl, 3~8 membered (un)saturated heterocyclic group, (aryl/heteroaryl) substituted with 0~4 R11; R9 is selected from C1~6 alkyl, halogen; R10 is selected from C1~6 alkyl, C1~4 alkoxy, halogen substituted by 0~4 R12]. Further [R11 is selected from C1~6 alkyl substituted by 0~4 R12′, halogen; R12 and R12′ are independently selected from halogen, hydroxyl, amino; R2 is selected from H, C1~6 alkyl substituted with 0~4 R14 substituted 3~10 membered cycloalkyl, R13 is selected from 3~6-membered (un)saturated heterocyclic groups, carboxyl, aryl substituted with 0~3 R15, amide group, etc.; R14 is selected from C1~6 alkyl, carboxyl, R15 is selected from halogen, C1~4 alkoxy, R3 is selected from 5-fluoroindoline.]. The compound prepared by the present invention has a strong binding capacity with B2 protein, especially with PB2318-483 protein, so that it can block the transcription process of influenza RNA polymerase, thereby inhibiting the proliferation of influenza virus, hence can be used to prepare drugs against influenza virus. The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).Electric Literature of 87486-34-8
The Article related to fluoropyrrolopyridinyl aminopyrazinone preparation anti influenza activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 87486-34-8