Magalhaes, Carla M.; Gonzalez-Berdullas, Patricia; Duarte, Diana; Correia, Ana Salome; Rodriguez-Borges, Jose E.; Vale, Nuno; Esteves da Silva, Joaquim C. G.; Pinto da Silva, Luis published an article in 2021, the title of the article was Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect.Computed Properties of 55779-48-1 And the article contains the following content:
Photodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivatives of coelenterazine, a chemiluminescent single-mol. widespread in marine organisms. Our results indicate that the use of the heavy-atom effect allows these mols. to generate readily available triplet states in a chemiluminescent reaction triggered by a cancer marker. Cytotoxicity assays in different cancer cell lines showed a heavy-atom-dependent anticancer activity, which increased in the substituent order of hydroxyl < chlorine < bromine. Furthermore, it was found that the magnitude of this anticancer activity is also dependent on the tumor type, being more relevant toward breast and prostate cancer. The compounds also showed moderate activity toward neuroblastoma, while showing limited activity toward colon cancer. In conclusion, the present results indicate that the application of the heavy-atom effect to marine coelenterazine could be a promising approach for the future development of new and optimized self-activating and tumor-selective sensitizers for light-free PDT. The experimental process involved the reaction of 8-Benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one(cas: 55779-48-1).Computed Properties of 55779-48-1
The Article related to coelenterazine anticancer synthesis heavy atom, cancer, chemiluminescence, coelenterazine, heavy-atom effect, photodynamic therapy, self-activating photosensitizers, triplet chemiexcitation and other aspects.Computed Properties of 55779-48-1