On May 28, 2015, Laurent, Alain; Rose, Yannick published a patent.Recommanded Product: 3-(8-Chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone The title of the patent was Preparation of 8-aminoimidazo[3,4-a]pyrazine as Btk protein kinase inhibitors. And the patent contained the following:
The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec and Src protein kinase families. The present invention also relates to processes for the preparation of these compounds [I; X = CH or N; R = H or each (un)substituted alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl; W = OCH2R11 or CH2OR11; R1 = each (un)substituted aryl or heteroaryl; X1, X2 = H or halogen; m, m1 = an integer from O to 4] or pharmaceutically acceptable salts, solvates, solvates of salts, stereoisomers, tautomers, isotopes, prodrugs, complexes or biol. active metabolites thereof, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, inflammatory and autoimmune diseases, disorders or conditions in which protein kinase activity is implicated. Thus, a solution of intermediate (II) (300 mg), intermediate (III) (397 mg), N,N-dimethylglycine (231 mg), cesium carbonate (1.1 g) and copper(I) iodide (141 mg) in 1,4-dioxane (1.5 mL) was heated in a pressure vessel at 110° overnight and then cooled to room temperature, followed by adding Et acetate, adsorbing the resulting mixture on silica gel, and purification by silica gel chromatog. to give 8-amino-1-(4-phenoxyphenyl)imidazo[3,4-a]pyrazine derivative (IV) as yellow solid. The experimental process involved the reaction of 3-(8-Chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone(cas: 936901-72-3).Recommanded Product: 3-(8-Chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone
The Article related to aminoimidazopyrazine aminophenoxyphenylimidazopyrazine preparation btk protein kinase inhibitor, proliferative disease inflammatory disease inflammatory autoimmune disease treatment aminoimidazopyrazine and other aspects.Recommanded Product: 3-(8-Chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone