On March 8, 2012, Currie, Kevin S.; Wang, Xiaojing; Young, Wendy B. published a patent.Product Details of 87486-34-8 The title of the patent was Preparation of pyridinones and pyrazinones as Btk kinase inhibitors for treating inflammation, immunological disorders, cancer, and other diseases. And the patent contained the following:
Pyridinone and pyrazinone compounds of Formula I (wherein R1 is substituted isoindolinone, thienopyrrolone, or pyrrolothiazolone; R2 is H, Me, or CF3; ring B is ring B is Ph, 5-6 membered heteroaryl, or 8-11 membered heterocyclyl; R3 is H, halo, cyano, etc.; R6 is H, Me, F, etc.; R7 is H, Me F, etc.; R8 is H, Me, CF3, etc.; V is CH or N) including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase are claimed. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathol. conditions, are disclosed. Synthetic procedures for preparing I are exemplified. Example compound II, prepared in a multistep synthesis that culminated in the cyclization of III, had an IC50 of 0.0364 in a standard biochem. Btk kinase assay. The experimental process involved the reaction of 3,5-Dibromo-1-methylpyrazin-2(1H)-one(cas: 87486-34-8).Product Details of 87486-34-8
The Article related to preparation pyridinone pyrazinone btk kinase inhibitor therapy diagnosis, immune disorder treatment pyridinone pyrazinone btk kinase inhibitor, inflammation cancer treatment pyridinone pyrazinone btk kinase inhibitor and other aspects.Product Details of 87486-34-8