Tunes, Luiza Guimaraes; Goncalves, Vivian Nicolau; Bueno, Daniela Nabak; Zani, Carlos Leomar; Rosa, Luiz Henrique; Cota, Betania Barros published the artcile< Diketopiperazine alkaloids produced by the endophytic fungus Penicillium citrinum and evaluation of their antileishmanial activity>, Product Details of C11H18N2O2, the main research area is Penicillium citrinum antileishmanial endophytic fungus diketopiperazine alkaloid.
Chromatog. fractionation of the antileishmanial extract obtained from fermentation of the endophytic fungus Penicillium citrinum, isolated from leaves of Ageratum myriadenia, yielded three diketopiperazine alkaloids; cyclo(L-Pro-L-Leu) (1), cyclo-(L-Pro-L-Phe) (2) and tryprostatin B (3). The structures of these compounds were established on the basis of spectroscopic methods and comparison with the literature. Compounds 1 and 2 were active against both amastigote-like forms of Leishmania (Leishmania) amazonensis and intracelular amastigotes of L. (Leishmania) infantum with approx. 50% of parasite growth inhibition at 100μM. None of the compounds were considered toxic against human leukemia monocyte cell line (THP-1) at 100μM. It is the first report about isolation of these diketopiperazines from P. citrinum and their antileishmanial potential against L. (L.) infantum.
African Journal of Microbiology Research published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Product Details of C11H18N2O2.