Mosrin, Marc; Knochel, Paul published the artcile< TMPZnCl·LiCl: A New Active Selective Base for the Directed Zincation of Sensitive Aromatics and Heteroaromatics>, Electric Literature of 136866-30-3, the main research area is tetramethylpiperidide zinc chloride reagent selective zincation aromatic heteroaromatic substrate; aryl heteroaryl zinc intermediate preparation coupling electrophile aryl allyl.
A wide range of polyfunctional aryl and heteroaryl Zn reagents were efficiently prepared in THF via direct zincation using TMPZnCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidide), a new exceptionally mild and efficient base. Activated arenes and heteroarenes are metalated at room temperature Remarkably, sensitive functions such as an aldehyde as well as a nitro group are tolerated, expanding significantly the scope of directed metalations.
Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl and heteroaryl). 136866-30-3 belongs to class pyrazines, and the molecular formula is C4HCl2IN2, Electric Literature of 136866-30-3.