Gajbhiye, Milind; Kapadnis, Balu published the artcile< Lactococcus lactis subsp. cremoris of Plant Origin Produces Antifungal Cyclo-(Leu-Pro) and Tetradecanoic Acid>, Application In Synthesis of 2873-36-1, the main research area is Lactococcus cyclic dipeptide tetradecanoic acid antifungal fungal infection; Biocontrol; Cyclo-(Leu-Pro); Lactic acid bacteria; Pomegranate; Tetradecanoic acid.
Abstract: The antifungal cyclo-depeptide and the fatty acid were isolated and purified from an indigenous strain of Lactococcus lactis subsp. cremoris. Maximal activity was observed at pH 5.5 and 6.5, and at 30°C under stationary conditions, which was detected in the culture supernatant 8 h post-inoculation in MRS broth until 22 h. The activity of antifungal compounds in the culture supernatant was sensitive to pH and temperature; and was protease-resistant. The antifungal compounds were concentrated by freeze-drying and ultrafiltration with activity retained in 1 kDa filtrates indicating low mol. weight metabolites. The compounds were further extracted by using different solvents amongst which, Et acetate provided the highest recovery. Antifungal compounds were separated on a silica gel column into two active fractions that were revealed to be tetradecanoic acid and cyclo-(Leu-Pro), a cyclic dipeptide, by GC-MS. Herein, we describe and attribute the biocontrol potential of L. lactis subsp. cremoris to the low mol. weight antifungal compounds isolated, which is the first report of their isolation from this strain. The broad antifungal spectrum of this candidate advocates further exploration of its biocontrol potential in managing fungal infections in different food and feed systems.
Indian Journal of Microbiology published new progress about Cyclic dipeptides Role: PRP (Properties). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Application In Synthesis of 2873-36-1.