Cao, Duc Danh; Trinh, Thi Thanh Van; Mai, Huong Doan Thi; Vu, Van Nam; Le, Hong Minh; Thi, Quyen Vu; Nguyen, Mai Anh; Duong, Thu Trang; Tran, Dang Thach; Chau, Van Minh; Ma, Rui; Shetye, Gauri; Cho, Sanghyun; Murphy, Brian T.; Pham, Van Cuong published the artcile< Antimicrobial lavandulylated flavonoids from a sponge-derived Streptomyces sp. G248 in East Vietnam Sea>, Quality Control of 2873-36-1, the main research area is Streptomyces antimicrobial lavandulylate flavonoid; Streptomyces; actinomycete; anti-microbial; anti-tuberculosis; cytotoxicity; flavonoid.
Three new lavandulylated flavonoids, (2S,2S)-6-lavandulyl-7,4-dimethoxy-5,2-dihydroxylflavanone (1), (2S,2-S)-6-lavandulyl-5,7,2,4-tetrahydroxylflavanone (2), and (2S)-5-lavandulyl-2-methoxy-2,4,4,6-tetrahydroxylchalcone (3), along with seven known compounds 4-10 were isolated from culture broth of Streptomyces sp. G248. Their structures were established by spectroscopic data anal., including 1D and 2D NMR (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configurations of 1-3 were resolved by comparison of their exptl. and calculated electronic CD spectra. Compounds 1-3 exhibited remarkable antimicrobial activity. Whereas, two known compounds 4 and 5 exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv with min. inhibitory concentration (MIC) values of 6.0 μg/mL and 11.1 μg/mL, resp.
Marine Drugs published new progress about Antimicrobial agents. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Quality Control of 2873-36-1.