Blair, Victoria L.; Blakemore, David C.; Hay, Duncan; Hevia, Eva; Pryde, David C. published the artcile< Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)2 and applications in in situ cross coupling reactions>, Computed Properties of 136866-30-3, the main research area is zincation nitrogen heterocycle reactant quench iodine reagent iodoheterocycle preparation; heteroarylzincate preparation palladium catalyzed Negishi cross coupling arylheterocycle preparation.
This study investigates the ability of the mixed-metal reagent [Li(TMP)Zn(tBu)2] (I) to promote direct Zn-H exchange reactions (zincations) of a wide range of N-heterocyclic mols. The generated metalated intermediates from these reactions are intercepted with I2 to yield iodoheterocycles, e.g. 3-iodo-2-methoxypyridine, and some of them are also employed as precursors in Pd-catalyzed Negishi cross-coupling applications yielding arylated N-heterocycles, e.g. 4-(4-chlorophenyl)-2-methoxypyridine. A comparison with recent precedents in metalation chem. reveals that for some of these heterocycles, I allows improved conversions, under milder conditions and in certain cases, even gives unique regioselectivities.
Tetrahedron Letters published new progress about Group 12 element compounds, zincates Role: FMU (Formation, Unclassified), RCT (Reactant), FORM (Formation, Nonpreparative), RACT (Reactant or Reagent). 136866-30-3 belongs to class pyrazines, and the molecular formula is C4HCl2IN2, Computed Properties of 136866-30-3.