Yu, Shui; Zhu, Yuan-Xing; Peng, Cheng; Li, Jiyang published the artcile< Two new sterol derivatives isolated from the endophytic fungus Aspergillus tubingensis YP-2>, Formula: C11H18N2O2, the main research area is ergosterimide sterol derivative endophyte fungus Aspergillus; Aspergillus tubingensis; cytotoxicities; demethylincisterol A5; endophytic fungus; ergosterimide B; secondary metabolites.
Two new sterol derivatives, namely ergosterimide B (1) and demethylincisterol A5 (2), along with eleven known metabolites (3-13), were isolated from the rice fermentation culture of Aspergillus tubingensis YP-2. The chem. structures were elucidated by detailed NMR and MS spectroscopic data and by comparison with reported data. Newly isolated compound and known compound were evaluated for their cytotoxicities against the A549 and HepG2 cell lines. Compound showed weak activities with IC50 values of 11.05 and 19.15μM, resp., while exhibited cytotoxicities with IC50 values of 5.34 and 12.03μM, resp., against the tested cell lines.
Natural Product Research published new progress about Cytotoxicity. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Formula: C11H18N2O2.