Yang, Jian; Zhao, Binbin; Qian, Li; Gao, Fengjie; Fan, Yanjuan; He, Xiaoyan; Ma, Qingyan; Yang, Lihong; Yan, Bin; Wang, Wei; Ma, Xiancang published the artcile< Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study>, Formula: C11H18N2O2, the main research area is genetically determined metabolite human intelligence metabolic pathway; 5-Oxoproline; Genetically determined metabolite; Human intelligence; Mendelian randomization; Metabolic pathway.
Intelligence predicts important life and health outcomes, but the biol. mechanisms underlying differences in intelligence are not yet understood. The use of genetically determined metabotypes (GDMs) to understand the role of genetic and environmental factors, and their interactions, in human complex traits has been recently proposed. However, this strategy has not been applied to human intelligence. Here we implemented a two-sample Mendelian randomization (MR) anal. using GDMs to assess the causal relationships between genetically determined metabolites and human intelligence. The standard inverse-variance weighted (IVW) method was used for the primary MR anal. and three addnl. MR methods (MR-Egger, weighted median, and MR-PRESSO) were used for sensitivity analyses. Using 25 genetic variants as instrumental variables (IVs), our study found that 5-oxoproline was associated with better performance in human intelligence tests (PIVW = 9.25 x 10-5). The causal relationship was robust when sensitivity analyses were applied (PMR-Egger = 0.0001, PWeighted median = 6.29 x 10-6, PMR-PRESSO = 0.0007), and repeated anal. yielded consistent result (PIVW = 0.0087). Similarly, also dihomo-linoleate (20:2n6) and p-acetamidophenylglucuronide showed robust association with intelligence. Our study provides novel insight by integrating genomics and metabolomics to estimate causal effects of genetically determined metabolites on human intelligence, which help to understanding of the biol. mechanisms related to human intelligence.
Molecular Brain published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (AACSP1). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Formula: C11H18N2O2.