Scales, Stephanie; Johnson, Sarah; Hu, Qiyue; Do, Quyen-Quyen; Richardson, Paul; Wang, Fen; Braganza, John; Ren, Shijian; Wan, Yadong; Zheng, Baojiang; Faizi, Darius; McAlpine, Indrawan published the artcile< Studies on the Regioselective Nucleophilic Aromatic Substitution (SNAr) Reaction of 2-Substituted 3,5-Dichloropyrazines>, Formula: C4HCl2IN2, the main research area is regioselective nucleophilic aromatic substitution reaction substituted dichloropyrazine.
Differences in regioselectivity were observed during the SNAr reaction of amines with unsym. 3,5-dichloropyrazines. This study revealed that when the 2-position of the pyrazine was occupied with an electron-withdrawing group (EWG), nucleophilic attack occurred preferentially at the 5-position. When the 2-position was substituted with an electron-donating group (EDG), nucleophilic attack occurred preferentially at the 3-position. These results are reported along with a computational rationale for the exptl. observations based on the Fukui index at the reacting centers.
Organic Letters published new progress about Aromatic substitution reaction (nucleophilic, regioselective). 136866-30-3 belongs to class pyrazines, and the molecular formula is C4HCl2IN2, Formula: C4HCl2IN2.