Lu, Shengsheng; Hu, Jianan; Xie, Xi; Zhou, Runhong; Li, Fangfang; Huang, Ruifeng; He, Jian published the artcile< Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equusquagga>, Synthetic Route of 2873-36-1, the main research area is Equus Streptomyces secondary metabolites feces; Streptomyces sp. BM-8; aliphatic acid; animal intestinal bacteria; cytotoxic activities; secondary metabolites.
A new aliphatic acid, compound 1, together with six known metabolites, including nonactic acid (2), homononactic acid (3), Et homononactate (4), homononactylhomononactate (5), valinomycin (6), and cyclo-(Pro-Leu) (7), was isolated from the culture broth of Streptomyces sp. BM-8, an actinobacterial strain isolated from the feces of Equus quagga. The structures of these compounds were established by analyses of spectroscopic data, including 1D and 2D NMR spectra (NMR), as well as by HR-ESI-MS spectrometry and chem. derivative analyses. Addnl., a serial analog of nonactic acid and homononacticacid (8-21) was synthesized. The cytotoxicity of 1-21 wastested against a panel of cancer cell lines, such as HT-29, MCF-7, A375 and K562, with MTT assay. In addition, the cytotoxicity tests revealed that 1 was less cytotoxic toward a panel of cancerous cells, as compared with valinomycin (6).
Molecules published new progress about Colon neoplasm. 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, Synthetic Route of 2873-36-1.