Cardenas, Paco; Gamage, Jayani; Hettiarachchi, Chamari M.; Gunasekera, Sunithi published the artcile< Good Practices in Sponge Natural Product Studies: Revising Vouchers with Isomalabaricane Triterpenes>, HPLC of Formula: 2873-36-1, the main research area is isomalabaricane triterpene sponge natural product; Porifera; Rhabdastrella globostellata; chemotaxonomy; isomalabaricane triterpenes; misidentification; vouchers.
Species misidentification in the field of natural products is an acknowledged problem. These errors are especially widespread in sponge studies, albeit rarely assessed and documented. As a case study, we aim to revisit reports of isomalabaricane triterpenes, isolated from four demosponge genera: Jaspis, Geodia, Stelletta and Rhabdastrella. From a total of 44 articles (1981-2022), 27 unique vouchers were listed, 21 of which were accessed and re-examined here: 11 (52.4%) of these were misidentified. Overall, 65.9% of the studies published an incorrect species name: previously identified Jaspis and Stelletta species were all in fact Rhabdastrella globostellata. We conclude that isomalabaricane triterpenes were isolated from only two Rhabdastrella species and possibly one Geodia species. In addition to shedding a new light on the distribution of isomalabaricane triterpenes, this study is an opportunity to highlight the crucial importance of vouchers in natural product studies. Doing so, we discuss the impact of species misidentification and poor accessibility of vouchers in the field of sponge natural products. We advocate for stricter voucher guidelines in natural product journals and propose a common protocol of good practice, in the hope of reducing misidentifications in sponge studies, ensure reproducibility of studies, and facilitate follow-up work on the original material.
Marine Drugs published new progress about Fatty acids, Me esters Role: PAC (Pharmacological Activity), BIOL (Biological Study) (Globostellatic acid). 2873-36-1 belongs to class pyrazines, and the molecular formula is C11H18N2O2, HPLC of Formula: 2873-36-1.