Pyrazine is a heterocyclic aromatic organic compound with the chemical formula C4H4N2. It is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. 22047-25-2, formula is C6H6N2O, Name is Acetylpyrazine. It is a deliquescent crystal or wax-like solid with a pungent, sweet, corn-like, nutty odour. Safety of Acetylpyrazine.
Malarz, Katarzyna;Zych, Dawid;Gawecki, Robert;Kuczak, Michal;Musiol, Robert;Mrozek-Wilczkiewicz, Anna research published 《 New derivatives of 4′-phenyl-2,2′:6′,2”-terpyridine as promising anticancer agents》, the research content is summarized as follows. Terpyridine derivatives are known from their broad application including anticancer properties. In this work authors present the newly synthesized 4′-phenyl-2,2′:6′,2”-terpyridine group with high antiproliferative activity. It was suggested that these compounds influence cellular redox homeostasis. Cancer cells are particularly susceptible to any changes in the redox balance because of their handicapped and inefficient antioxidant cellular systems. The antiproliferative activity of the studied compounds was tested on five different cell lines that represent several types of tumors; glioblastoma, leukemia, breast, pancreatic and colon. Addnl., their selectivity towards normal cells also tested. Mol. biol. studies are performed in order to detect the response of a cell to its treatment with the compounds that were tested. Authors looked at the in-depth changes in the proteins and cellular pathways that lead to cell cycle inhibition (G0/G1 and S), and consequently, death on the apoptosis and autophagy pathways. It was proved that the studied compounds targeted DNA as well. Special attention was paid to the targets connected with ROS generation.
22047-25-2, 2-Acetylpyrazine has been identified as one of the volatile flavor constituents in popcorn, wheat and rye bread crust.
2-Acetylpyrazine, also known as 1-pyrazinylethanone or fema 3126, belongs to the class of organic compounds known as aryl alkyl ketones. These are ketones have the generic structure RC(=O)R’, where R = aryl group and R’=alkyl group. 2-Acetylpyrazine exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 2-acetylpyrazine is primarily located in the cytoplasm. 2-Acetylpyrazine has a bitter, bread crust, and chip taste.
2-acetylpyrazine is a pyrazine that is substituted by an acetyl group at position 2. It has been identified as one of the volatile flavor constituents in popcorn, bread crust, vinegar, and potato snacks. It has a role as a flavouring agent. It is an aromatic ketone and a member of pyrazines.
2-Acetylpyrazine is a nitrogen containing compound that has been used in biological studies. 2-Acetylpyrazine has been shown to have inhibitory properties against the growth of prostate cancer cells and other cell lines. It also inhibits the production of fatty acids and epidermal growth factor, which are important for cellular proliferation. The inhibition is due to the photochemical properties of 2-acetylpyrazine, which cause the formation of reactive species that react with biological molecules. The reactive species may be generated by either a reaction mechanism or a reaction pathway that involve coordination geometry. 2-acetylpyrazine has also been used as a fluorescence probe for fatty acid detection in lipid bilayers and liposomes., Safety of Acetylpyrazine