The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Amino-2-fluoropyridine(SMILESS: NC1=CN=C(C=C1)F,cas:1827-27-6) is researched.Recommanded Product: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The article 《Three Arene-Ru(II) compounds of 2-halogen-5-aminopyridine: Synthesis, characterization, and cytotoxicity》 in relation to this compound, is published in Applied Organometallic Chemistry. Let’s take a look at the latest research on this compound (cas:1827-27-6).
Three novel compounds, (η6-p-cymene)RuCl2(2-fluoro-5-aminopyridine) (compound 1), (η6-p-cymene)RuCl2(5-amino-2-chloropyridine) (compound 2) and (η6-p-cymene)RuCl2(2-bromo- 5-aminopyridine) (compound 3), were synthesized and characterized. The structures of compound 1 and 3 were determined by x-ray diffraction, showing a distorted piano-stool type of geometry with similar bond lengths and angles around the Ru. Compound 2 exhibited moderate in vitro activity against A549 and MCF-7 human cancer cells, the other two lower activities. The UV-visible and fluorescent absorption titrations showed that the three compounds bonded with CT-DNA in a minor groove. The intrinsic binding constants (Kb) were calculated to be 2.13(±0.03) × 105 M-1, 2.89(±0.03) × 105 M-1 and 2.45(±0.03) × 105 M-1 for compound 1, 2 and 3, resp., by using UV-visible absorption titrations data. Among the three compound, the highest value of intrinsic binding constant of compound 2 was consistent with its high cytotoxicity against A549 and MCF-7 human cancer cells in vitro.
Although many compounds look similar to this compound(1827-27-6)COA of Formula: C5H5FN2, numerous studies have shown that this compound(SMILES:NC1=CN=C(C=C1)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.