The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Aminopyrimidine( cas:591-54-8 ) is researched.Product Details of 591-54-8.Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas published the article 《Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis》 about this compound( cas:591-54-8 ) in Bioconjugate Chemistry. Keywords: palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis. Let’s learn more about this compound (cas:591-54-8).
A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.
Although many compounds look similar to this compound(591-54-8)Product Details of 591-54-8, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.