Spletstoser, Jared T.; Dreabit, Jason; Knox, Andrew N.; Benowitz, Andrew; Campobasso, Nino; Ward, Paris; Cui, Guanglei; Lewandowski, Thomas; McCloskey, Lynn; Aubart, Kelly M. published an article about the compound: 4-Aminopyrimidine( cas:591-54-8,SMILESS:C1=CN=CN=C1N ).HPLC of Formula: 591-54-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:591-54-8) through the article.
The discovery of a novel series of peptide deformylase inhibitors incorporating a piperazic acid amino acid found in nature is described. These compounds demonstrated potent in vitro enzymic potency and antimicrobial activity. Crystal structure anal. revealed the piperazic acid optimized a key contact with the PDF protein that accounted for the increased enzymic potency of these compounds We describe lead optimization of the P3′ region of the series that resulted in a compound with good potency against three target organisms. One mol. showed in vivo efficacy in a rat respiratory infection model but ultimately did not meet candidate progression criteria.
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