The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ) is researched.COA of Formula: C4H6N2O2S.Logue, Brian A.; Maserek, Wendy K.; Rockwood, Gary A.; Keebaugh, Michael W.; Baskin, Steven I. published the article 《The analysis of 2-amino-2-thiazoline-4-carboxylic acid in the plasma of smokers and non-smokers》 about this compound( cas:2150-55-2 ) in Toxicology Mechanisms and Methods. Keywords: forensic analysis ATCA plasma human smoker GC MS; cyanide poisoning biomarker ACTA plasma human smoker GC MS; gas chromatog mass spectrometry ACTA plasma human cyanide poisoning. Let’s learn more about this compound (cas:2150-55-2).
ATCA (2-amino-2-thiazoline-4-carboxylic acid) is a promising marker to assess cyanide exposure because of several advantages of ATCA anal. over direct determination of cyanide and alternative cyanide biomarkers (i.e. stability in biol. matrixes, consistent recovery, and relatively small endogenous concentrations). Concentrations of ATCA in the plasma of smoking and nonsmoking human volunteers were analyzed using gas chromatog. mass spectrometry to establish the feasibility of using ATCA as a marker for cyanide exposure. The levels of ATCA in plasma of smoking volunteers, 17.2 ng/mL, were found to be significantly (p < 0.001) higher than that of nonsmoking volunteers, 11.8 ng/mL. Comparison of ATCA concentrations of smokers relative to nonsmokers in both urine and plasma yielded relatively similar results. The concentration ratio of ATCA for smokers vs. nonsmokers in plasma and urine was compared to similar literature studies of cyanide and thiocyanate, and correlations are discussed. This study supports previous evidence that ATCA can be used to determine past cyanide exposure and indicates that further studies should be pursued to validate the use of ATCA as a marker of cyanide exposure. Although many compounds look similar to this compound(2150-55-2)COA of Formula: C4H6N2O2S, numerous studies have shown that this compound(SMILES:O=C(C1N=C(N)SC1)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.