The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Formula: C6H7NO3.Webb, Michael R.; Addie, Matthew S.; Crawforth, Catherine M.; Dale, James W.; Franci, Xavier; Pizzonero, Mathieu; Donald, Craig; Taylor, Richard J. K. published the article 《The syntheses of rac-inthomycin A, (+)-inthomycin B and (+)-inthomycin C using a unified synthetic approach》 about this compound( cas:118994-89-1 ) in Tetrahedron. Keywords: asym synthesis inthomycin B C Mukaiyama aldol reaction; Stille coupling reaction asym synthesis inthomycin A B C. Let’s learn more about this compound (cas:118994-89-1).
The Stille coupling between a common oxazole vinyl iodide and stereodefined stannyl-diene units is described as the cornerstone of a unified synthetic route to the inthomycin family of bioactive Streptomyces metabolites. This procedure has been utilized to prepare (+)-inthomycin B (I) and (+)-inthomycin C (II) for the first time; in these examples the stereogenic center was introduced using the Kiyooka ketene acetal/amino acid-derived oxazaborolidinone variant of the Mukaiyama aldol reaction. In addition, a convenient preparation of rac-inthomycin A (III) is described based on the same strategy.
After consulting a lot of data, we found that this compound(118994-89-1)Formula: C6H7NO3 can be used in many types of reactions. And in most cases, this compound has more advantages.