So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Piou, Tiffany; Slutskyy, Yuriy; Kevin, Nancy J.; Sun, Zhongxiang; Xiao, Dong; Kong, Jongrock researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Application of 118994-89-1.They published the article 《Direct Arylation of Azoles Enabled by Pd/Cu Dual Catalysis》 about this compound( cas:118994-89-1 ) in Organic Letters. Keywords: oxazole aryl halide palldium copper catalyst arylation; ethyl aryl oxazole carboxylate preparation. We’ll tell you more about this compound (cas:118994-89-1).
A practical approach toward the synthesis of 2-arylazoles via direct arylation was described. The transformation relied on a Pd/Cu cocatalyst system that operated with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.
Although many compounds look similar to this compound(118994-89-1)Application of 118994-89-1, numerous studies have shown that this compound(SMILES:O=C(C1=CN=CO1)OCC), has unique advantages. If you want to know more about similar compounds, you can read my other articles.