So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Meyer, Claudio F.; Hell, Sandrine M.; Misale, Antonio; Trabanco, Andres A.; Gouverneur, Veronique researched the compound: 4-Aminopyrimidine( cas:591-54-8 ).Name: 4-Aminopyrimidine.They published the article 《Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid》 about this compound( cas:591-54-8 ) in Angewandte Chemie, International Edition. Keywords: alkene difluoroacetic acid regioselective phenyliodine diacetate hydrodifluoromethylation light; hydrodifluoromethylated alkane preparation; difluoroacetic acid; hydrodifluoromethylation; hypervalent iodine compounds; photochemistry; radicals. We’ll tell you more about this compound (cas:591-54-8).
A facile method for the regioselective hydrodifluoromethylation of alkenes is reported using difluoroacetic acid and phenyliodine(III) diacetate in THF under visible-light activation. This metal-free approach stands out as it uses inexpensive reagents, does not require a photocatalyst, and displays broad functional group tolerance. The procedure is also operationally simple and scalable, and provides access in one step to high-value building blocks for application in medicinal chem.
Although many compounds look similar to this compound(591-54-8)Name: 4-Aminopyrimidine, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.