The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Safety of Ethyl oxazole-5-carboxylate.Enriquez-Garcia, Alvaro; Ley, Steven V. published the article 《Total synthesis of the potent antifungal agents bengazole C and E》 about this compound( cas:118994-89-1 ) in Collection of Czechoslovak Chemical Communications. Keywords: antifungal bengazole C E total synthesis. Let’s learn more about this compound (cas:118994-89-1).
The bengazoles are marine natural products with unique structure, containing two oxazole rings flanking a single carbon. They show very potent antifungal activity. The total syntheses of bengazole C and E are described following a convergent route which involves diastereoselective cycloaddition of an appropriately substituted nitrile oxide with a butane-1,2-diacetal-protected alkenediol as the key step.
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