Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1827-27-6, is researched, SMILESS is NC1=CN=C(C=C1)F, Molecular C5H5FN2Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides, Author is Mukherjee, Paramita; Woroch, Cristian P.; Cleary, Leah; Rusznak, Mark; Franzese, Ryan W.; Reese, Matthew R.; Tucker, Joseph W.; Humphrey, John M.; Etuk, Sarah M.; Kwan, Sabrina C.; am Ende, Christopher W.; Ball, Nicholas D., the main research direction is calcium triflimide sulfonyl fluoride amine nucleophilic addition; sulfonamide synthesis.HPLC of Formula: 1827-27-6.
A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.
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