So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bream, Robert N.; Clark, Hugh; Edney, Dean; Harsanyi, Antal; Hayler, John; Ironmonger, Alan; Mc Cleary, Nadine; Phillips, Natalie; Priestley, Catherine; Roberts, Alastair; Rushworth, Philip; Szeto, Peter; Webb, Michael R.; Wheelhouse, Katherine researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).COA of Formula: C6H7NO3.They published the article 《The Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib.》 about this compound( cas:118994-89-1 ) in Organic Process Research & Development. Keywords: Nemiralisib improved preparation. We’ll tell you more about this compound (cas:118994-89-1).
The development of an improved and scalable method for the manufacture of Nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor was studied. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in pilot plant on multikilogram scale to deliver >100 kg of product.
In some applications, this compound(118994-89-1)COA of Formula: C6H7NO3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.