So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sather, Aaron C.; Martinot, Theodore A. researched the compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole( cas:121816-79-3 ).Recommanded Product: 121816-79-3.They published the article 《Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles》 about this compound( cas:121816-79-3 ) in Organic Process Research & Development. Keywords: data experimentation palladium catalyzed coupling piperidine heterocyclic electrophile. We’ll tell you more about this compound (cas:121816-79-3).
To circumvent a current limitation in palladium-catalyzed C-N cross-coupling methodol., high-throughput experimentation was used to identify a catalyst capable of fusing piperidine-based nucleophiles with five-membered (hetero)aromatic bromides. A decomposition pathway for the standard electrophile was found, and a base screen was used to identify conditions that suppress this undesired transformation. Building on this, systematic optimization using a Design of Experiments approach delivered mild reaction conditions that were then subsequently applied to a variety of coupling partners.
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