Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 118994-89-1, is researched, Molecular C6H7NO3, about The Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib., the main research direction is Nemiralisib improved preparation.Application of 118994-89-1.
The development of an improved and scalable method for the manufacture of Nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor was studied. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in pilot plant on multikilogram scale to deliver >100 kg of product.
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