The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole(SMILESS: O=[N+](C1=NC(Br)=CN1C)[O-],cas:121816-79-3) is researched.Synthetic Route of C5H5FN2. The article 《Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:121816-79-3).
A four-step synthesis of 5-[N,N-bis(2-chloroethyl)amino]-1-methyl-2-nitroimidazole from 1-methyl-2-nitroimidazole is described. This compound showed similar hypoxia-selective cytotoxicity to the dinitrobenzamide mustard SN 23862 in UV4 cells (ca. 40-fold), and superior selectivity (>7-fold) in repair-competent AA8 cells.
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