Ryu, Ok Hee; Shin, Chul Soo published the article 《Enzymatic characteristics in the bioconversion of D,L-ATC to L-cysteine》. Keywords: aminothiazolinecarboxylate metabolism enzyme Pseudomonas; cysteine formation enzyme Pseudomonas.They researched the compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ).Application In Synthesis of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2150-55-2) here.
The bioconversion of DL-2-aminothiazoline-4-carboxylic acid (I) to L-cysteine (II) was investigated. After the intracellular enzyme of a Pseudomonas species was inducibly formed by addition of I in the middle of culture, the cells were isolated and treated with sonication to prepare the crude enzyme solution I was the only isomeric form of the amino acid produced from I and its production could be enhanced several 10-fold by addition of Mn2+ which was required as a cofactor in the enzymic reaction. In addition, this reaction suffered from feedback inhibition of II. On the other hand, since a II-decomposing enzyme coexisted in the crude enzyme solution, most of the II formed disappeared in the absence of its inhibitor. However, hydroxylamine was a potent inhibitor which could successfully prevent the decomposition of II.
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