Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2150-55-2, is researched, SMILESS is O=C(C1N=C(N)SC1)O, Molecular C4H6N2O2SJournal, Article, Research Support, Non-U.S. Gov’t, Biochemistry (Moscow) called Metabolic control analysis of L-cysteine producing strain TS1138 of Pseudomonas sp, Author is Huai, Lihua; Chen, Ning; Yang, Wenbo; Bai, Gang, the main research direction is model cysteine Pseudomonas metabolic control analysis.Application of 2150-55-2.
A kinetic model describing the biosynthesis of L-cysteine by Pseudomonas sp. TS1138 has been developed. The two enzymes catalyzing this pathway, L-cysteine synthetase (CS) and L-cysteine desulfhydrase (CD), follow Michaelis-Menten kinetics with noncompetitive inhibition of CS by L-cysteine. From measurements of intermediates and end products that were made during L-cysteine enzymic synthesis, metabolic control anal. of the pathway was carried out using the kinetic model. The elasticity coefficients and the flux control coefficients were calculated, and the anal. revealed a shift in the flux control from CS to CD during the reaction. The findings further implicate potential targets and strategies for increasing L-cysteine production; for example, the strain TS1138 could be manipulated by site-directed mutagenesis to reduce CD activity.
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