The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid(SMILESS: O=C(C1N=C(N)SC1)O,cas:2150-55-2) is researched.Application In Synthesis of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The article 《LC-MS/MS method development and validation for quantitative analyses of 2-aminothiazoline-4-carboxylic acid – a new cyanide exposure marker in post mortem blood》 in relation to this compound, is published in Talanta. Let’s take a look at the latest research on this compound (cas:2150-55-2).
2-Aminothiazoline-4-carboxylic acid (ATCA) is a hydrogen cyanide metabolite that has been found to be a reliable biomarker of cyanide poisoning, because of its long-term stability in biol. material. There are several methods of ATCA determination; however, they are restricted to extraction on mixed mode cation exchange sorbents. To date, there has been no reliable method of ATCA determination in whole blood, the most frequently used material in forensic anal. This novel method for ATCA determination in post mortem specimen includes protein precipitation, and derivatization of interfering compounds and their later extraction with Et acetate. ATCA was quant. analyzed via HPLC-tandem mass spectrometry with pos. electrospray ionization detection using a hydrophilic interaction liquid chromatog. column. The method satisfied all validation criteria and was tested on the real samples with satisfactory results. Therefore, this anal. approach has been proven to be a tool for measuring endogenous levels of ATCA in post mortem specimens. To conclude, a novel, accurate and sensitive method of ATCA determination in post mortem blood was developed. The establishment of the method provides new possibilities in the field of forensic science.
From this literature《LC-MS/MS method development and validation for quantitative analyses of 2-aminothiazoline-4-carboxylic acid – a new cyanide exposure marker in post mortem blood》,we know some information about this compound(2150-55-2)Safety of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, but this is not all information, there are many literatures related to this compound(2150-55-2).