The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Detoxication of cyanide by cystine》. Authors are Wood, John L.; Cooley, Shirley Lucille.The article about the compound:2-Amino-4,5-dihydrothiazole-4-carboxylic acidcas:2150-55-2,SMILESS:O=C(C1N=C(N)SC1)O).Category: pyrazines. Through the article, more information about this compound (cas:2150-55-2) is conveyed.
cf. C.A. 46, 5633a. Chem. studies on the nature of the reaction product between cystine and cyanide support formulation of the structure as 2-imino-4-thiazolidinecarboxylic acid (I). I was inert metabolically when fed to the rat or injected. I with acid yielded a small amount of thiocyanate. I was isolated from the urine of rats given NaCN subcutaneously; 80% of the cyanide was accounted for as thiocyanate. When L-cystine-S35 was administered 1st, the compounds excreted were labeled. Radioactivity measurements showed that I came from cystine, while the thiocyanate was formed from other sources of S. The reaction with cystine constitutes an independent pathway for detoxification of cyanide. The method of Schöberl and Hamm (C.A. 43, 1014f) yielded 66% I, m. 212°, [α]D29 -2.18° (c 1, water). I with Raney Ni yielded alanine. I with Ac2O in alk. aqueous solution yielded the 3-Ac compound (II), m. 179-80°, [α]D29 -1.52° (c 1, water). I (5 g.) in EtOH saturated with dry HCl and allowed to stand 24 hrs. yielded 5 g. Et ester-HCl, m. 115-16°. The Et ester of II, m. 136°.
From this literature《Detoxication of cyanide by cystine》,we know some information about this compound(2150-55-2)Category: pyrazines, but this is not all information, there are many literatures related to this compound(2150-55-2).