The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Reference of Ethyl oxazole-5-carboxylate.Piou, Tiffany; Slutskyy, Yuriy; Kevin, Nancy J.; Sun, Zhongxiang; Xiao, Dong; Kong, Jongrock published the article 《Direct Arylation of Azoles Enabled by Pd/Cu Dual Catalysis》 about this compound( cas:118994-89-1 ) in Organic Letters. Keywords: oxazole aryl halide palldium copper catalyst arylation; ethyl aryl oxazole carboxylate preparation. Let’s learn more about this compound (cas:118994-89-1).
A practical approach toward the synthesis of 2-arylazoles via direct arylation was described. The transformation relied on a Pd/Cu cocatalyst system that operated with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.
Here is just a brief introduction to this compound(118994-89-1)Reference of Ethyl oxazole-5-carboxylate, more information about the compound(Ethyl oxazole-5-carboxylate) is in the article, you can click the link below.