The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid( cas:2150-55-2 ) is researched.Safety of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid.Ryu, Ok Hee; Shin, Chul Soo published the article 《Analysis of the reaction steps in the bioconversion of D,L-ATC to L-cysteine》 about this compound( cas:2150-55-2 ) in Journal of Microbiology and Biotechnology. Keywords: cysteine preparation aminothiazolinecarboxylate enzyme Pseudomonas. Let’s learn more about this compound (cas:2150-55-2).
The reaction steps involved in the bioconversion of a chem. synthesized precursor, D,L-2-amino-Δ2-thiazoline-4-carboxylic acid (D,L-ATC), to L-cysteine and the properties of the involved enzymes were investigated. It was found that the conversion consisted of two steps, i.e., D,L-ATC to S-carbamyl-L-cysteine (S-C-L-cysteine) and S-C-L-cysteine to L-cysteine, and the S-C-L-cysteine was an intermediate between them. While the enzymes involved in the reactions were induced by the addition of D,L-ATC as an inducer, S-C-L-cysteine induced only the enzyme involved in the latter step. The conversion of S-C-L-cysteine to L-cysteine could be also carried out in the presence of hydroxylamine and its rate was much faster than that by the corresponding enzyme. On the other hand, L-cysteine (or L-cystine) was decomposed to evolve H2S by the enzyme considered to be a kind of desulfhydrase. However, hydroxylamine was a perfect inhibitor for this enzyme.
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